Simplified Signal Decoding Systems in the Mechanistic Account of the Explanation of the Secondary Immune Response (in Polish)

Tomasz Rzepiński

About author

Tomasz Rzepiński, dr hab.
Adam Mickiewicz University
Department of Philosophy
ul. Szamarzewskiego 89c
Pl-60-568 Poznań

E-mail: rzepinskit@wp.pl

Abstract


The paper deals with the procedure of explaining the secondary immune response. First, the basic concepts of the mechanistic account of explanation developed by Machamer, Darden and Craver will be considered. Subsequently, I will focus on the concepts describing the activation of the elements of the immunological system viewed as a signal decoding process. The analysis will make it possible to argue for the thesis that the explanations of the secondary immune response, formulated in immunology, aim to describe the possible procedures of simplifying the signal decoding process. The following considerations will make it possible to show the specificity of the mechanistic explanations formulated in immunology, and to demonstrate their significance for medical sciences.

Full Text:

PDF (In Polish)


References


  1. T. Brzeziński, Choroby, ich rozprzestrzenianie i historia, [w:] Historia medycyny, T. Brzeziński (red.), Wydawnictwo Lekarskie PZWL, Warszawa 1995, s. 114-122.
  2. N. Bushar, D. Farber, Recalling the Year in Memory T Cells, „Annals of the New York Academy of Science” (1143) 2008, s. 212-225.
  3. P. Champagne, A. Dumont, R. Sekaly, Learning to remember: generation and maintance of T-cell memory, „DNA and Cell Biology” (20/12), 2001, s. 745-760.
  4. C. Craver, Explaining the Brain. Mechanisms and the Mosaic Unity of Neuroscience, , Oxford University Press, Oxford 2007.
  5. S. Crotty, R. Ahmed, Immunological memory in humans, „Seminars in Immunology” (16) 2004, s. 197-203.
  6. D. Farber, T Cell Memory: Heterogenity and Mechanism, „Clinical Immunology” (95/3) 2000, s. 173-181.
  7. D. Farber, Remembrance of Antigens Past: New Insights into Memory T Cells, „Scandinavian Journal of Immunology” (58) 2003, s. 145-154.
  8. S. Garcia, J. DiSanto, B. Stockinger, Following development of a CD4 T cell response in vivo: from activation to memory formation, „Immunity” (11) 1991, s. 163-71.
  9. T. Gourley, E. Wherry, D. Masopust, R. Ahmed, Generation and maintance of immunological memory, „Seminars in Immunology” (16) 2004, s. 323-333.
  10. D. Gray, Immunological memory: a function of antigen persistence, „Trends in Microbiology” (1) 2001, s. 39-41.
  11. D. Gray, P. Matzinger, T cell memory is short-lived in the absence of antigen, „The Journal of Experimental Medicine” (174/5) 1991, s. 969-974.
  12. P. Grzesiowski, W. Hryniewicz, Immunologia szczepień ochronnych, [w:] Immunologia, J. Gołąb, M. Jakóbisiak, W. Lasek (red.), Wydawnictwo Naukowe PWN, Warszawa 2005, s. 356-371.
  13. C. Hempel, Aspects of Scientific Explanation and other Essays in the Philosophy of Science, The Free Press, New York 1965.
  14. M. Jakóbisiak, Główne komponenty i zasadnicze cechy odpowiedzi immunologicznej, [w:] Immunologia, J. Gołąb, M. Jakóbisiak, W. Lasek (red.), Wydawnictwo Naukowe PWN, Warszawa 2005, s. 1-6.
  15. S. Kaech, E. Wherry, R. Ahmed, Effector and memory T-cell differentiation: implications for vaccine development, Nature Reviews Immunology (2) 2002, s. 251-62.
  16. K. Kozar, R. Zagożdżon, Aktywacja limfocytów, [w:] Immunologia, J. Gołąb, M. Jakóbisiak, W. Lasek (red.), Wydawnictwo Naukowe PWN, Warszawa 2005, s. 176-197.
  17. P. Machamer, L. Darden L., C. Craver, Thinking about Mechanisms, Philosophy of Science, (67/1) 2000, s. 1-25.
  18. M. Maruyama, K. Lam, K. Rajewsky, Memory B-cell persistence is independent of persisting immunizing antygen, “Nature”, (407) 2000, s. 636-42.
  19. P. McLaughlin, What Function Explain – Functional Explanation and Self-Reproducing Systems, Cambridge University Press, Cambidge 2001.
  20. E. Nagel, The Structure of Science – Problems in the Logic of Scientific Explanation, Routledge & Kegan Paul, London 1960.
  21. M. Nervi, Mechanisms, Malfunction and Explanation in Medicine, “Biology & Philosophy”, 25(2), 2010, s. 215-228.
  22. T. Rzepiński, Wyjaśnianie funkcjonalno-przyczynowe i jego rola w projektowaniu farmakologicznych terapii kardioprotekcyjnych, „Filozofia Nauki” (3/83) 2013, s. 99-121.
  23. T. Rzepiński, Charakterystyka systemów dekodowania sygnału w mechanistycznej teorii wyjaśnień, „Filozofia Nauki” (3/87) 2014, s. 81-104.
  24. A. Saalmuller, New understanding of immunological mechanisms, „Veterinary Microbiology” (117) 2006, s. 32-38.
  25. W. Salmon, Scientific Explanation and the Causal Structure of the World, Princeton University Press, Princeton 1984.
  26. P. Thagard, Pathways to Biomedical Discovery, „Philosophy of Science” 70(2) 2003, s. 235-254.
  27. Zinkernagel, Bachmann, Kundig, i współ. [1996] – R. Zinkernagel, M. Bachmann, T. Kundig, i współ. On immunological memory, „Annual Review of Immunology” (14) 1996, s. 333-67.

DOI:

http://dx.doi.org/10.13153/diam.50.2016.976

Article links:

Default URL: http://www.diametros.iphils.uj.edu.pl/index.php/diametros/article/view/976
Polish abstract URL: http://www.diametros.iphils.uj.edu.pl/index.php/diametros/article/view/976/pl
English abstract URL: http://www.diametros.iphils.uj.edu.pl/index.php/diametros/article/view/976/en

Share:






All works are licensed under a Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License.